Endocrine Abstracts

Introduction: Graves’ disease (GD) is an autoimmune thyroiditis frequently associated with development of Graves’ orbitopathy (GO). GD patients have lower vitamin D levels compared to the general population. Whether low vitamin D levels are associated with GO is still controversial. The aim of our study was to assess the vitamin D levels in patients with GO and the clinical outcome.Methods: This is a single-center observational study in an outp...

Introduction: Patients with multiple sclerosis (MS) demonstrate, in a number of studies, increased risk of acquiring another autoimmune disease compared to general population. Autoimmune thyroid diseases, type 1 diabetes, psoriasis and inflammatory bowel disease are the most common reported. The aim of our study is to determine potential factors that affect the presence of autoimmune endocrinopathies in patient with relapsing and remitting MS.Methods: We...

Introduction: Only few studies were observed, supporting the hypothesis that the administration of high doses of vitamin E in people with elevated serum total cholesterol levels leads to increased adrenocortical hormone secretion. There are only limited data concerning androgen or estrogen levels. The aim of this study is to investigate the possible effect of Vitamin E on adrenal and sex hormones in rabbits with hypercholesterolemia, as an animal model for the research.<p ...

Introduction: Patients with Graves’ disease (GD) and thyroid nodules have an elevated risk of developing papillary thyroid carcinoma (PTC). Distant metastasis observed in 1-9% of patients with PTC. The classical subtype usually demonstrates favorable prognosis compared to other more aggressive PTC subtypes, for which an increased risk of extranodal metastases is observed.Aim of the Study: We present an unusual case of a young male diagnosed with cla...

Introduction: Graves orbitopathy (GO) is an inflammatory condition of the orbital fat and muscles and affect 30-50% of patients with Graves’ disease. The first-line treatment of moderate to severe GO according to EUGOGO is intravenous glucocorticoids, but 20-30% of the cases appear to be corticosteroid resistant or refractory. Promising results have been described with Tocilizumab (TCZ) as a second-line moderate to severe GO treatment.Case presentat...

Introduction: The prevalence of lymph node metastasis from micropapillary thyroid carcinoma (mPTC) in different studies is up to 33%. Preoperative diagnosis of central lymph node (CLN) metastasis is essential for the surgical management of those patients. Prophylactic CLN dissection for patients with mPTC is controversial. Our study aimed to assess the prevalence and the risk factors of LMN metastasis in patients mPTC Methods: We retrospectively study th...

Introduction: Graves’ Orbitopathy (GO), the most common extrathyroidal manifestation of Graves’ disease (GD), usually presents bilateral disease. However, a minority of patients present with unilateral disease, the prevalence of which is between 4,5% and 14%. The aim of our study is to evaluate the specific demographic and clinical characteristics and potential differences between bilateral and unilateral GO, and the association with disease activity and severity.</p...

Introduction: Hyalinizing trabecular tumors are extremely rare and uncommon thyroid tumors, which were first described by Carney et al. Until now, their preoperative diagnosis based on cytological characteristics is not possible, because of the lack of specific features and molecular markers.Case presentation: We present a 38-year-old Caucasian female, non-smoker, with a disease-free medical history, with a right-sided clearly delimited large hy...

Introduction: Latent autoimmune diabetes of the adults (LADA) is a heterogeneous type of diabetes sharing clinical characteristics of type 2 DM and serum markers of pancreatic autoimmunity detected in type 1 DM. It accounts for 2-12% of all patients with diabetes. The aim of our study is to identify the association between LADA and other systemic or organ-specific autoimmune diseases.Materials and Methods: We conducted an observational study in the outpa...

IntroductionA strong association between autoimmune atrophic gastritis and other autoimmune disorders has been well documented. The prevalence of gastric mucosa alterations in patients with thyroid autoimmunity is not well known. The aim of our study was to assess the prevalence of intestinal metaplasia in patients with Graves’ disease (GD) and positive anti-parietal cell antibodies (APCA).Methods<p class=...